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Supplementary Table 3

In the optic nerves of ocular hypertensive rats, mitophagosome numbers increased 3 days after elevated IOP, but within 2 weeks, these numbers decreased, leading to the belief that mitophagy may be upregulated to combat stress, but with chronic elevation, mitophagic mechanisms fail and may become impaired (Dai et al., 2018)

Epigenetic regulation of sex-specific hepatic gene expression Another key factor influencing liver metabolism and HCC is epigenetics, encompassing global DNA hypomethylation of oncogenes, hypermethylation of tumor suppressors, histone modifications that alter chromatin accessibility, chromatin-loop rearrangements facilitating enhancerpromoter oncogenic interactions, and post-transcriptional regulation via microRNAs and RNA modifications [144]

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